JOSHA’s Critical Review of “CAR T Cells – A New Horizon for Autoimmunity” by John D. Isaacs

The editorial discusses the potential of CD19-targeted CAR T cell therapy in managing autoimmune diseases. Published in The New England Journal of Medicine on February 22, 2024, the author highlights a pilot study by Müller et al. revealing promising outcomes, including remission and discontinuation of immunosuppressive medication, in 15 patients with systemic autoimmunity with a single infusion. While the therapy shows potential, it is also associated with adverse effects such as cytokine-release syndrome and long-term complications. However, further research is needed to address these concerns. If confirmed through extended follow-up, CAR T cell therapy could revolutionise autoimmune disease treatment, offering a comprehensive approach to disease management.This excellent editorial from Dr. Issacs is worth reading!