Demetrios Preis 2018: “Comparison of preclinical characterization methods of a radioactive pharmaceutical agent”

This is one of the four works that have been selected by our JOSHA-editors as a winner of our Demetrios Preis 2018! The Thesis was presented by Simon Osterkamp from Germany. Neuroendocrine Tumors (NET) are relatively rare tumors with an incidence 0f 35 per 100000 in the USA. They express the Somatostatin Receptor (SST-R) which specifically binds the radioactive agent DOTATATE. The objective of the research presented here was to investigate whether saturation with 68Ga-DOTATATE with [68Ga]Ga3+ has an effect on the KD. Furthermore, a protocol was to be developed which would allow measuring the KD-Value by IC50- determination via "Vakuum-Stanzer".